Aim-

Serum levels of vitamin D derivatives in bronchial asthma patients and their correlation with disease markers were assessed in a study.

Method-

• The study enrolled 113 subjects, divided into two groups.
• Group 1 included 73 asthmatic patients (57 males, 16 females).
• Group 2 served ascontrol group and included 40 healthy adults (31 males, 9 females).
• The participants were subjected to complete history and clinical examination, posteroanterior view chest X-ray, routine laboratory investigations, spirometry, and asthma control tests (ACT).
• Ultra-performance liquid chromatography (UPLC) with tandem mass spectrometry was utilized to assess vitamin D serum levels.
• Disease markers [forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC%, peak expiratory flow (PEF), forced expiratory flow25-75% (FEF25-75%), eosinophilic blood count, total immunoglobulin E (IgE)] were assessed and matched-up with serum levels of vitamin D forms. 

Results-

Reference-

Al-Thagfan SS, Ahmed S, Emara MM, Awadallah MF. Impacts of deficiency in vitamin D derivatives on disease severity in adult bronchial asthma patients. Pulm Pharmacol Ther. 2021:102073.