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Heat Shock Protein-70 Levels and Oxidative Damage in Bronchopulmonary Dysplasia

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eMediNexus    31 August 2021

Heat shock protein-70 (Hsp-70) exhibits cytoprotective effects against oxidative stress-induced airway injury.

A new study published in Frontiers in Pediatrics aimed to examine Hsp-70 and 8-hydroxy-2-deoxyguanosine (8-OHdG) from tracheal aspirates (TA) in very low-birth weight (VLBW) preterm infants – to predict the development of bronchopulmonary dysplasia (BPD). 2

The present birth cohort study identified 109 VLBW preterm infants, including 32 infants who developed BPD. 

It was observed that Hsp-70 and 8-OHdG levels in TA fluid were persistently increased from day 1 to day-28 of life, in the BPD group. The results showed that BPD was significantly associated with gestational age, respiratory distress syndrome and TA Hsp-70 and 8-OHdG levels, on the post-natal day-28. Meanwhile, the TA Hsp-70 level positively correlated with TA 8-OHdG level on the day 1 and day-28 of life. Additionally, incubation of recombinant Hsp-70 with primary epithelial cells derived from TA of patients decreased hydrogen peroxide-induced epithelial cell death. 

From the observations, it was concluded that Hsp-70 levels are associated with a state of oxidative injury in the development of BPD.

Source: Frontiers in Pediatrics. 2021 May 26;9:616452. doi: 10.3389/fped.2021.616452.

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