Aim-

A study determined the efficacy of awake prone positioning in preventing intubation or death in patients with severe COVID-19.

Methods

• It was a large-scale randomized, prospective, a priori set up and defined, collaborative meta-trial of six randomized controlled open-label superiority trials.
• Awake prone positioning or standard care were randomly assigned to adults patients who needed respiratory support with a high-flow nasal cannula for acute hypoxemic respiratory failure due to COVID-19.  
• Hospitals from Canada, France, Ireland, Mexico, the USA, and Spain were involved in the study.
• Patients and their care providers were not masked about the treatment given.
• The outcome was treatment failure, explained as the proportion of patients intubated or dying within 28 days of enrolment. 

Results-

Reference-

Ehrmann S, Li J, Ibarra-Estrada M, Perez Y, et al. Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial. Lancet Respir Med. 2021 Aug 20;S2213-2600(21)00356-8.