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MicroRNA-155: A potential Biomarker for Allergic Rhinitis in Children

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eMediNexus    07 September 2021

Aim-

  • A study evaluated the role of miR-155 as a biomarker in AR
  • It also assessed the association between its level and the total nasal symptom score (TNSS) and the levels of serum interleukin-4 (IL-4). 

Methods- 

  • 90 children - 45 with pollen-induced AR and 45 healthy controls - were enrolled in the study.
  • Quantitative real-time PCR was used to measure serum miR-155 expression levels.
  • Human IL-4 ELIZA kits were utilized for the semiquantitative detection of the serum levels of IL-4.

Results- 

Conclusion-
  • MiR-155 expression levels are raised in the serum of children with AR and so, miR-155 can be used as a biomarker in diagnosing the condition.

Reference-

Hammad NM, Nabil F, Elbehedy EM, et al. Role of MicroRNA-155 as a Potential Biomarker for Allergic Rhinitis in Children. Can Respir J. 2021 Jun 10;2021:5554461.

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