Aim-

A study assessed the efficacy and safety of ivy leaves’extract cough formulation in the treatment

Method-

• This randomized, placebo-controlled, double-blind trial included 181 adult patients with acute cough.
• Enrolled subjects were treated with either ivy leaves’ extract cough formulation or placebo 3 times/day for one week.
• The efficacy outcome was the assessment of cough severity (CS) by Visual Analogue Scale (VAS) over the treatment period over 7 days (visit (V)1, V2, V3, V4, and V5).
• Assessment of CS by VAS over the whole observation period (V1 - V6) and by Bronchitis Severity Score (BSS) and Verbal Category Descriptive (VCD) score were the secondary endpoints.

Results-

Reference-

Schaefer A, Kehr MS, Giannetti BM, Bulitta M, Staiger C. A randomized, controlled, double-blind, multi-center trial to evaluate the efficacy and safety of a liquid containing ivy leaves dry extract (EA 575®) vs. placebo in the treatment of adults with acute cough. Pharmazie. 2016 Sep 1;71(9):504-509. doi: 10.1691/ph.2016.6712. PMID: 29441845.