Young adults with pediatric liver disease demand different evaluation and monitoring strategies, treatment, complications, and comorbidities, creating a critical need for a successful transition into adult care. This can be fulfilled by incorporating a formal transitional model and a multidisciplinary team.

Cholestasis in children is of different etiology adults. Genetically inherited causes are the most common etiology in this population. Cholestasis in children may result from biliary tract obstruction as in biliary atresia or defects in forming and excreting bile acids and other components of bile. 

Biliary atresia patients may have the following implications in adulthood-Progressive liver fibrosis, cirrhosis Portal hypertension with variceal hemorrhage Cholangitis, Hepatopulmonary syndrome and portopulmonary hypertension, Hepatocellular carcinoma, need for liver transplant

Along with the medical comorbidities, this population may also show signs of impaired psychosocial functioning and quality of life. 

Source: Selvakumar PKC, Hupertz V, MittalN, Kowdley KV, Alkhouri N. Pediatric cholestatic liver disease: Successful transition of care, Cleveland Clinic Journal of Medicine, 2019; 86 (7): 454-464.