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eMediNexus 07 October 2021
A randomized double-blind placebo-controlled study assessed the effect of combination probiotic Saccharomyces boulardii CNCM-I 3799 and Bacillus subtilis CU-1 in the outpatient management of acute watery diarrhea in children.
The study enrolled 180 participants aged between six months to five years with acute mild to moderate diarrhea and was randomized to receive S. boulardii CNCM-I 3799 and B. subtilis CU-1 or a placebo accompanied with oral rehydration salts and zinc supplementation.
The patients were followed up for three months for the recurrence of diarrhea.
The observations from the study were as follows-
Thus S. boulardii CNCM-I 3799 and B. subtilis CU-1 combination was found to be effective in reducing the duration of diarrhea on the administration within 48 hours of diarrhea onset. Furthermore, in the subsequent three months, it also reduced the recurrence of diarrhea and its intensity.
Source: Pediatr Gastroenterol Hepatol Nutr. 2021 Sep;24(5):423-431. doi: 10.5223/pghn.2021.24.5.423. Epub 2021 Sep 8. PMID: 34557395; PMCID: PMC8443851.
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