An observational study has shown that patients with liver disease had two-times higher incidence of cardiovascular disease (CVD), compared to individuals who did not have liver disease, with marked geographical variations.

Investigators used electronic health records (EHRs) for around four million adults in England and evaluated the incidence of CVD in patients with one of the five liver conditions, including alcoholic liver disease, autoimmune liver disease, hepatitis B, hepatitis C, and nonalcoholic fatty liver disease. They assessed the first record of a cardiovascular presentation in five CVD categories, namely coronary heart disease, strokes and transient ischemic attack, peripheral vascular disease, cardiomyopathy, and arrhythmia. It was found that the age-standardized incidence rate for any liver disease was 114.5 per 100,000 person years (95% CI, 112.5 - 116.6). Additionally, the age-standardized incidence rate for CVD in patients with liver disease was 2634.6 per 100,000 person years (95% CI, 2524.4 - 2744.8) compared to 1339.7 per 100,000 person years (95% CI, 1332.3 - 1347) for people without liver disease… (Medscape)