Organ damage changes in patients with resistant hypertension.


eMediNexus    15 January 2018

A new study published in the Journal of Clinical Hypertension compared effects of renal denervation and spironolactone treatments for resistant hypertension on preclinical target organ damage. In this study, 24 patients with 24-hour systolic blood pressure ≥140 mm Hg were randomized to receive spironolactone or renal denervation; all these patients had been on three or more full-dose antihypertensive drugs. It was found that at 6 months, the mean baseline-adjusted difference between the two groups with respect to 24-hour systolic blood pressure was -17.9 mm Hg. While, mean baseline-adjusted change in urine albumin excretion was -87.2 and -23.8, respectively. Additionally, mean baseline-adjusted variation of 24-hour pulse pressure was -13.5 and -2.1, respectively. Further, the correlation of change in 24-hour systolic blood pressure with change in log-transformed urine albumin excretion was 0.713. Therefore, the results indicated that at 6 months, there was a decrease in albuminuria in patients with resistant hypertension treated with spironolactone as compared to renal denervation.

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