Psoriasis is a chronic inflammatory autoimmune which is associated with a negative impact on social and interpersonal relationships. Poor drug penetration through the skin, hyper-pigmentation, and a burning sensation on normal and diseased skin are the common problems encountered with the conventional treatments for psoriasis. These are overcome by colloidal drug delivery systems, along with showing improved patient safety parameters, compliance, superior effectiveness and reduced toxicity.  

Numerous colloidal drug delivery approaches are widely used such as emulsion systems-i.e., multiple emulsion, microemulsion, and nano-emulsion; vesicular systems-i.e., liposomes, ethosomes, noisomes, and transferosomes; and particulate systems-i.e., solid lipid nanoparticles, solid lipid microparticles, nano-structured lipid carriers, dendrimers, nanocrystals, polymeric nanoparticles, and gold nanoparticles.  

The recent studies on colloidal approaches for psoriasis management indicate that colloidal pharmaceutical formulations should be investigated broadly as they have the potential to effectively manage many skin disorders in the coming decades.

Source: Pharmaceutics. 2021 Nov 22;13(11):1978. doi: 10.3390/pharmaceutics13111978. PMID: 34834393.