Liver Update: Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis |
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Liver Update: Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis

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Acute alcoholic hepatitis causes unbalanced macrophage inflammatory cytokine responses to bacterial lipopolysaccharide. Lack of knowledge of the underlying mechanism has restricted the invention of effective therapy. A study hypothesized a novel mechanism that causes ethanol to boost histone acetylation, augmenting proinflammatory gene transcription and cytokine synthesis. Human macrophage cell lines cultured in 86 mM ethanol, 1 mM acetate, and normal media were assessed for their Cytokine ...
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