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#Gastroenterology #Hepatology #Multispeciality
Liver transplantation (LT) for alcohol-associated liver disease (ALD) demands Alcohol abstinence before LT. However, some patients might relapse, leading to LT in patients with non-abstinence during the pretransplant period. No data exist regarding the Long-term survival outcomes of these patients.
A study determined if alcohol consumption on the day of the LT influences the long-term survival after LT. A retrospective case-control study was conducted among French LT centers. LT recipients with positive blood and/or urine alcohol levels on the day of LT were considered as cases. 2 controls were matched for every case resembling patients transplanted for ALD during the same trimester.
Patients were categorized into 3 groups as per their alcohol consumption as
- occasional or transitory excessive consumers,
- patients with sustained excessive consumption (daily consumption >20-30 g/day).
The following observations were made-
- 3052 LTs for ALD were recorded.
- 42 cases paired with 84 controls were included.
- Median blood alcohol and urine alcohol levels were found to be 0.4 g/L and 0.2 g/L, respectively.
- 12.9 years was the Median follow-up period until death or censoring.
- Similarities in Long-term survival were observed between the groups.
- Case group showed greater relapse to any alcohol consumption rate (59.5%) than the control group.
- Sustained excessive consumption was not found to be markedly different between the groups (33.3% and 29.8% in case and control groups respectively).
- The case group demonstrated more frequent rates of recurrent cirrhosis and cirrhosis-related deaths.
Thus, non-abstinence during the immediate pretransplant period does not cause impaired long-term survival in patients despite greater relapse and recurrent cirrhosis rates.
Source- Ursic-Bedoya J, Dumortier J, Altwegg R, Belkacemi M, Vanlemmens C, Dharancy S et al. Alcohol Consumption the Day of Liver Transplantation for Alcohol-Associated Liver Disease Does Not Affect Long-Term Survival: A Case-Control Study, Hepatology, 2021;27(1):34-42.