A multicenter retrospective study determined the demographics, clinical presentation, and maternal and neonatal outcomes in patients diagnosed with acute fatty liver of pregnancy over 10 years.

The following observations were made-

• 16 cases of acute fatty liver of pregnancy were included in the study. 
• 11 cases were diagnosed in the antepartum period, while 5 cases were diagnosed within 4 days after delivery.
• 18% among which had multiple gestations. 
• The most frequent symptoms were Nausea and vomiting (75%).
• 5% maternal deaths and 15% fetal deaths were reported.

Thus the patients with persistent nausea, vomiting, or epigastric pain in the third trimester should receive an evaluation of liver enzymes, renal function, and a complete blood count to rule out the diagnosis of acute fatty liver of pregnancy.

Source- Fesenmeier MF, Coppage KH, Lambers DS, Barton JR, Sibai BM. Acute fatty liver of pregnancy in 3 tertiary care centers, American Journal of Obstetrics and Gynecology, 2005;192(5): 1416-1419. https://doi.org/10.1016/j.ajog.2004.12.035.