Obesity and overweight have become a global challenge and are significant health issues in the current health scenario. While reduction of body weight is the most appropriate strategy to treat overweight conditions, weight loss is also linked to metabolic changes, most of the favorable in improving the health of the individual. Weight loss has been shown to be directly linked to metabolic conditions such as hypertension, high blood glucose, lipid profiles, sleep apnoea, and comorbidities including non-alcoholic fatty liver disease, polycystic ovarian syndrome, infertility, and type 2 diabetes. 

Maintaining healthy body weight, particularly following weight reduction, needs equalized input and energy output to regulate optimal metabolism. This comprises a complex interplay of enzyme activity regulation, ATP synthesis, and utilization, hormonal functions, neurological and muscular activities. 

Besides, an important factor to be considered is that weight loss at a slow rate is better sustained than weight loss more rapidly. Further evidence has suggested that higher initial weight loss is positively related to long-term weight maintenance.     

Reference: Farhana A, Rehman A. Metabolic consequences of weight reduction. Stat Pearls. November 17. 2021. Accessed from https://www.ncbi.nlm.nih.gov/books/NBK572145/