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A Single-Cell Transcriptomic Atlas of Human Skin Aging

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eMediNexus    08 April 2022

The skin experiences constant self-renewal and its functional decline is a visible outcome of aging. Understanding human skin aging demands in-depth knowledge of the molecular and functional properties of various types of skin cells.

A recent study performed single-cell RNA sequencing of human eyelid skin from healthy individuals of different ages and identified eleven canonical cell types, along with six subpopulations of basal cells. Further analysis also demonstrated progressive accumulation of photoaging-related changes and increased chronic inflammation with age. Transcriptional factors involved in the developmental process experienced early-onset reduction during aging. Furthermore, inhibition of key transcription factors HES1 in fibroblasts and KLF6 in keratinocytes showed to compromise cell proliferation, increase inflammation and cellular senescence during aging. Finally, genetic activation of HES1 or pharmacological treatment with quercetin alleviated cellular senescence of dermal fibroblasts was found. 

These findings furnish a single-cell molecular framework of human skin aging, delivering a rich resource for developing therapeutic strategies against aging-related skin disorders.

Source- Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S et al. A Single-Cell Transcriptomic Atlas of Human Skin Aging. Developmental Cell. 2021;56(3): P383-397.E8. DOI:https://doi.org/10.1016/j.devcel.2020.11.002

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