Acute Kidney Injury may be followed by Many Fatal Electrolyte and Metabolic Abnormalities. 

Extracorporeal therapies as multiple-organ support therapy

• Extracorporeal therapy is the treatment of choice when disorders are life threatening or refractory to medical corrections. 

o It dissociates the removal of water from that of sodium or other electrolytes. 

• Cardiac support can be achieved by optimization of fluid balance, reduction or organ oedema, and restoration of desirable levels of preload and afterload. 

o Extracorporeal therapy enables significant cardiovascular stability, along with maintaining hemodynamic parameters including mean arterial pressure, heart rate, and systemic vascular resistance. 

Reference: Gaudry S, Pelevsky PM, Dreyfuss D. N Engl J Med. 2022; 386: 964-975.