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Albuminuria increases the risk for VTE in patients with normal eGFRs

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Dr Ramesh Hotchandani    29 January 2018

Albuminuria increases the risk for venous thromboembolism (VTE) remarkably in patients with normal estimated glomerular filtration rates (eGFRs) compared to those with lower eGFRs, suggests a study published in the American Journal of Kidney Diseases. The study evaluated the association of VTE events in patients by albuminuria and eGFR making use of large population-based databases. The study involved 694,956 adults in Ontario, Canada, from 2002 to 2012. In all, 15,180 (2.2%) VTE events were noted during the study period. Both albuminuria and eGFR had an independent association with VTE. The association of albuminuria and VTE differed by level of eGFR. Considering the competing risk for death, a 61% higher rate of VTE was evident in patients with normal eGFRs (eGFRs > 90 mL/min/1.73 m2) and heavy albuminuria (ACR > 300 mg/g) as compared to those with normal eGFRs and no albuminuria. Among patients with reduced kidney function (eGFR, 15–29 mL/min/1.73 m2), the risk for VTE was noted to increase only minimally, regardless of albuminuria. Chronic kidney disease (CKD), defined as reduced eGFR and/or albuminuria, is therefore, a significant independent risk factor for the development of VTE.

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