First oral drug for alopecia areata |
eMediNexus Coverage from: 
First oral drug for alopecia areata
Dr Veena Aggarwal, Consultant Womens’ Health, CMD and Editor-in-Chief, IJCP Group & Medtalks Trustee, Dr KK’s Heart Care Foundation of India,  15 June 2022
Coronavirus Live Count Map India

remove_red_eye 2216 Views
COVID-19 Vaccine Updates


3 Read Comments                

Oral baricitinib, a Janus kinase (JAK 1/2) inhibitor, has been approved by the US Food and Drug Administration (FDA) as once-daily treatment of severe alopecia areata, an autoimmune disorder, in adult patients making it the first systemic treatment for the condition. This approval is based on the findings of the BRAVE-AA1 and BRAVE-AA2 randomized, double-blind, placebo-controlled trials.

Side effects: Respiratory tract infections, headache, nausea, acne, fatigue, pain abdomen, hyperlipidemia, UTI, folliculitis, elevated creatinine phosphokinase and liver enzymes, anemia, neutropenia, herpes zoster, genital candidiasis,

Contraindications: Coadministration with other JAK inhibitors, biologic immunomodulators, cyclosporine or other strong immunosuppressants.

Warnings and precautions: Hypersensitivity, close observation of patients for infection during/after treatment; investigate patient for active/latent tuberculosis before starting treatment; likelihood of viral reactivation, gastrointestinal perforation, leukopenia, anemia

The drug carries a “boxed warning” for severe infections, mortality, major adverse cardiovascular events and thrombosis and malignancy.

To comment on this article ,
create a free account.
Sign Up to instantly read 30000+ free Articles & 1000+ Case Studies
Create Account

Already registered?

Login Now