Pregabalins effect on chemokines and its clinical effectiveness in 40 patients with neuropathic pain was examined in a recent study. The enrolled subjects were randomly divided into observation and control groups.

The observation group and the control group received treatment with pregabalin and gabapentin respectively. Extracted cerebrospinal fluid from the patients was subjected to detection of concentration levels of C-X3-C motif chemokine ligand 1, C-X-C motif chemokine ligand 1, C-X-C motif chemokine ligand 8 and C-C motif chemokine ligand 2. The concentration levels, the adverse drug reactions and clinical effects were compared between the groups.

Treatment showed a reduction in the concentration levels of cerebrospinal fluid chemokines C-X3-C motif chemokine ligand 1, C-X-C motif chemokine ligand 1, C-X-C motif chemokine ligand 8 and C-C motif chemokine ligand 2 in both groups. However, this change was more pronounced in the observation group along with a greater clinical remission rate than in the control group.

Thus it was inferred that pregabalin treatment reduces the chemokines in cerebrospinal fluid and relieves the pain of patients with neuropathic pain.