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COVID-19 Vaccine Updates
With inputs from Dr Monica Vasudev
Rebound symptoms in Covid-19
A new medRxiv preprint study has found that rebound symptoms occurred in about 27% of patients Covid-19 after their symptoms improved and in 10% patients after their symptoms had resolved. These patients had not received any antiviral drug. 12% tested positive again after earlier negative tests indicating a viral rebound. Women were more likely to experience rebound of symptoms, while the probability of viral rebound was higher in older patients. But the two were unlikely to occur together and was seen in 1-2% of patients…(Source: medRxiv, August 3, 2022).
Anosmia severity a better predictor of cognitive impairment
Severity of anosmia in Covid-19 is more predictive of cognitive impairment than the severity of the disease itself, suggests a study from Argentina presented at the recently concluded Alzheimers Association International Conference 2022. Olfactory dysfunction was present in 40%. Around 11.7% of the study subjects had memory-only impairment, 8% had impaired attention and executive function but no memory impairment, while nearly 11.6% had multiple domain impairment. Participants who had severe cognitive impairment also had anosmia…(Source: Medscape, July 31, 2022).
COVID Patients May Be Infectious Beyond 5 Days
— Small study found half of those with positive antigen test on day 6 had culturable virus
A JAMA Network Open study says that Covid-19 patients with a positive rapid antigen test after 5 days of the illness may remain infectious. On day 6, 75% had positive RAT and the virus could be cultured in 35% of them. All patients who had a negative RAT on day 6 also yielded a negative viral culture. Such patients with residual symptoms may be potential sources of infection. These observations highlight the necessity of masking up to the tenth day of the infection….(Source: JAMA Network Open, August 3, 2022).
EU says Novavax COVID shot must carry heart side-effect warning
The European Medicines Agency (EMA) has asked the manufacturers of Novavax Covid-19 vaccine to carry a warning about the risks of myocarditis and pericarditis in the product information…(Source: Reuters, August 3, 2022).