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DiabetesIndia 2022: 25 Years of Acarbose in India

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Dr BM Makkar, New Delhi    05 July 2022

  • In Indian patients considering a carbohydrate-rich diet, acarbose works by inhibiting alpha-glucosidase causing a delay in intestinal absorption of carbohydrates along with decreasing insulin need.
  • The structural uniqueness of the acarbose reduces PPG via an insulin-sparing mechanism and facilitates its entry into the large intestine.
  • Several studies have proved that acarbose reduces Hb1Ac by 0.8% along with a reduced risk of progression from prediabetes to type 2 diabetes.
  • Acarbose is recommended by various international communities owing to glucose-lowering efficacy across a broad range of patients, regardless of BMI, HbA1c, duration of diabetes, insulin resistance, condition of β cells, age, etc.

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