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Increased Frequency of Circulating Classical Monocytes in Patients with Rosacea

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eMediNexus    12 August 2022

The goal of a study was to assess the frequencies of monocyte subsets in peripheral blood mononuclear cells (PBMCs) from rosacea patients before and after clinical treatment.

The study group comprised 116 patients with rosacea in whose samples; flow cytometry was applied to examine frequencies of monocyte subsets. Patients with systemic lupus erythematosus (SLE), acne and normal healthy subjects without skin problems (HC) formed the control group.

The findings showed that the frequency of classical monocytes was higher in rosacea as compared with HC, which decreased after treatment. However, the frequency of intermediate or nonclassical monocytes remained the same. The frequencies of monocyte subsets showed no gender variation, nonetheless, they increased with age among the patients, but not in the HC. Frequencies of classical monocytes in patients with erythematotelangiectatic rosacea (ETR) and ETR-papulopustular rosacea (PPR) overlap were markedly raised than those in the HC or patients with only PPR or phymatous rosacea (PhR). Additionally, higher expression of C-C chemokine receptor 2 (CCR2) in classical monocytes was notable, with higher plasma levels of CC-chemokine ligand 2 (CCL2), high mobility group box-1 (HMGB-1), interleukin-1 β (IL-1β) and tumor necrosis factor-α (TNF-α) in patients than in HC. All these values significantly decreased after treatment.

Therefore, the results denoted that rosacea could be associated with abnormal classical monocytes frequencies.

Source: Gao C, Ge L, Chen D, et al. Increased frequency of circulating classical monocytes in patients with rosacea. Clin Cosmet Investig Dermatol. 2021;14:1629-36. 

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