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NAFLD and NASH links

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Dr Pramila Kalra, Bengaluru    31 January 2018

steatosis in >5% of hepatocytes according to histological analysis or by proton density fat fraction, or >5.6% as assessed by proton magnetic resonance spectroscopy or quantitative fat/water selective MRI with no secondary cause for steatosis. Conditions like alcohol abuse and hepatitis C infection need to be excluded. NAFL is a benign condition in which the fatty infiltration is simple and there is no inflammation. The liver function tests show slight increase in serum glutamic-pyruvic transaminase (SGPT) and serum glutamic oxaloacetic transaminase (SGOT) in some cases and liver USG or fibroscan reveals fatty liver. NASH is a condition in which there is fatty infiltration along with liver inflammation (steatohepatitis). The confirmation is done by liver biopsy. NASH occurs mostly in people who have features of metabolic syndrome, and liver enzyme elevation may be seen more than that seen in NAFL. NASH can progress to cirrhosis.

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