AGIs: Place in therapy in Indian T2DM patients


Dr Abhay Kumar Sahoo, Bhubaneswar    01 February 2018

 carbohydrates. Carbohydrate constitutes 64.1% of total energy from diet. PPG of 62.5% diabetic population was above the target of 180 mg/dl. Efforts are needed to raise awareness on the impact of postprandial hyperglycemia (PPHG) on CV risk. Relevance of a-glucosidase inhibitors (AGIs) for Indian patients: Indian diet is rich in carbohydrates; compared to western world, this is far higher; carbohydrate load determines the postprandial rise in blood glucose. There is a need to address this high carbohydrate meal either through diet modifications or the agent, which reduces the absorption of carbohydrate; AGIs primarily take care of PPG for comprehensive control. AGIs have long track record of safety and efficacy with benefits like weight reduction, low risk of hypoglycemia and CV protection. Patients with exaggerated postprandial excursion can be treated with acarbose. AGIs with metformin: Comprehensive glycemic control.

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