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LAICON 2022: International - Biochemistry and Genetics of Triglyceride

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Dr Mariko Harada-Shiba, Takatsuki    01 December 2022

  • Triglycerides (TGs) consist of fatty acids linked to one glycerol.
  • TGs are transported as core constituents of all lipoproteins.
  • TGs are hydrolyzed by LPL.
  • Pathogenic mutations in LPL, ApoC2, GPIHBP1, LMF1 and ApoA-V are the causes of monogenic chylomicronemia.
  • For treating familial chylomicronemia, dietary modification and lipid-lowering drugs, including fibrates, niacin and omega-3 fatty acids, are used, which have less efficacy.
  • For the treatment of familial chylomicronemia, anti-APOC3 antisense has been developed.
  • Several autoimmune diseases may cause hyperchylomicronemia due to anti-GPIHBP1.

 

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