Calcium (Ca) and magnesium (Mg) plays a crucial role in several cellular processes and are essential for the skeleton′s normal development and tissue homeostasis. A deficiency of these elements might delay bone fracture recovery or accelerates bone loss.

The present study examined whether supplementation of trace element (TE) promotes fracture healing in accidentally fracturing adults by the involvement of an inflammatory mechanism. It performed a short-term clinical follow-up. 

The study enrolled 117 subjects diagnosed with multiple fractures by traffic accidents. It measured Serum Ca and Mg levels by inductively coupled plasma atomic emission spectrophotometry; and detected Short-term changes such as Serum C-reactive protein, interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha in normal treatment and TE supplement groups by enzyme-linked immunosorbent assay. 

The study observed-

• Significant negative correlations between Ca and Mg and injury severity score.
• Significantly increased Serum Ca and Mg at Days 5, 7, and 9 following TE supplements.
• Significantly reduced serum C-reactive protein, IL-1β, IL-6, and tumor necrosis factor-alpha After treatment, whereas lower cytokine levels of the TE supplement group than the normal treatment group after Day 3.

These findings suggest that Ca and Mg levels are associated with the injury severity of multiple fractures. Their supplementation could reduce inflammation, benefiting bone recovery and disease processes.

2022 Jan 7;101(1):e28538. Doi: 10.1097/MD.0000000000028538. PMID: 35029924; PMCID: PMC8735799.