Moisturizers with anti-inflammatory or anti-itch activity should be developed to safely and effectively manage atopic dermatitis (AD). The present study evaluated the efficacy of a newly developed moisturizer, CSP0510 lotion, containing citric acid (CA) and trisodium phosphate (TSP) as active ingredients in mild to moderate AD.

It found:

• Improvement in the objective and subjective (itch) symptoms of AD after twice daily application of CSP0510 lotion for 4 weeks to eczematous lesions.
• A decrease in the physician′s global assessment (PGA) score for objective symptoms from 2.5 ± 0.6 before application to 1.3 ± 0.5 after application in the CSP0510-treated group.
• A decrease in the PGA score from 2.3 ± 0.6 to 1.9 ± 0.5 by vehicle-treated (without CA and TSP) control group, but no statistical difference between the CSP0510-treated and vehicle-treated groups.
• A decrease in the visual analog scale score for itch from 4.8 ± 1.3 to 2.0 ± 0.9 in the CSP0510-treated group and from 4.6 ± 1.1 to 3.5 ± 0.9 in the control group, showing a statistical significance between two groups.
• These results in humans were further supported by in vitro and animal experiments.
• CA:TSP (1:1, vol:vol) synergistically suppressed the compound 48/80-induced upregulation of thymic stromal lymphopoietin, nerve growth factor and calcitonin gene-related peptide, in HaCaT cells treated with compound 48/80 (7.5 µg/mL).
• Suppression of the oxazolone-induced allergic skin inflammation after applying CSP0510 to the dorsal skin of hairless mice for 3 weeks.

This study shows the anti-itch and anti-inflammatory activity of CSP0510 lotion in the skin, improving both objective and subjective AD symptoms.

Source: Lee HJ, Yang NW, Choi JY, et al. CSP0510 Lotion as a novel moisturizer containing citric acid and trisodium phosphate relieves objective and subjective symptoms of atopic dermatitis. Ann Dermatol. 2016;28(3):344-51.