Topical treatments for seborrheic keratoses


eMediNexus    06 January 2023

Seborrheic keratoses (SKs) are benign epidermal neoplasms occurring as waxy, brown-to-black papules and plaques. Patients frequently opt for removal due to cosmetic reasons or irritation. The present study assessed the efficacy and safety of topical treatments for SKs. It retrieved studies involving any topical medication indicated for SK removal from Embase, Scopus, PubMed, and Cochrane. 


The study found-


  • Topical treatments with a good-to-excellent response are hydrogen peroxide, Maxacalcitol 25 µg/g, BID Tazarotene 0.1% cream, 5% potassium dobesilate cream, 1% diclofenac sodium solution, urea-based solution, and 65% and 80% trichloroacetic acid.
  • They cause only mild and transient local skin reactions.
  • Topical hydrogen peroxide revealed the greatest evidence for clinical clearance of SKs, although no studies directly compared hydrogen peroxide to current first-line treatments (e.g., cryotherapy or shave excision). 


The study results illustrate the viable and safe treatment of SK with topical therapies; however, there remains a need for topical treatments that reliably equate or exceed the efficacy of current first-line therapies.


Natarelli N, Krenitsky A, Hennessy K, Moore S, Grichnik J. Efficacy and safety of topical treatments for seborrheic keratoses: a systematic review. Journal of Dermatological Treatment. 2022. DOI: 10.1080/09546634.2022.2133532

To comment on this article,
create a free account.

Sign Up to instantly get access to 10000+ Articles & 1000+ Cases

Already registered?

Login Now

Most Popular Articles

News and Updates

eMediNexus provides latest updates on medical news, medical case studies from India. In-depth medical case studies and research designed for doctors and healthcare professionals.