EXPLORE!

Improvements in Acne and Skin Oiliness with Tazarotene 0.045% Lotion in Patients with Oily Skin

  678 Views

eMediNexus    03 February 2023

Excessive sebum production promotes acne development. Tazarotene, 0.045% lotion, has been shown to reduce acne lesions and acne-induced sequelae.

 

The present study, thus evaluated the efficacy, changes in skin oiliness and safety of tazarotene 0.045% lotion in participants with moderate to severe acne and oily skin.

 

It enrolled participants aged ≥9 years with moderate to severe acne and randomized them 1:1 to once-daily tazarotene 0.045% lotion or vehicle lotion (n = 1,614). The study evaluated inflammatory/noninflammatory lesion counts, treatment success, skin oiliness, treatment-emergent adverse events (TEAEs) and cutaneous safety/tolerability. It observed:

 

  • Tazarotene provided greater reductions in inflammatory/noninflammatory lesions and greater treatment success rates versus vehicle at week 12 in all participants with oily skin (n = 793).
  • Subjective skin oiliness reductions by week 12 in over two-thirds of polymeric lotion-treated participants, and about a third reported ′low/not′ oily skin.
  • TEAE rates of tazarotene to be similar to the overall population.

 

This study shows that once-daily treatment with tazarotene 0.045% polymeric emulsion lotion may improve patient-perceived skin oiliness in people with moderate-to-severe acne.

 

Source: Tanghetti EA, Zeichner JA, Gold M, et al. Improvements in acne and skin oiliness with tazarotene 0.045% lotion in patients with oily skin. J Dermatolog Treat. 2022 Nov 16:1-22. 

To comment on this article,
create a free account.

Sign Up to instantly get access to 10000+ Articles & 1000+ Cases

Already registered?

Login Now

Most Popular Articles

News and Updates

eMediNexus provides latest updates on medical news, medical case studies from India. In-depth medical case studies and research designed for doctors and healthcare professionals.