Highly Purified Polynucleotide vs. Placebo for Treating Moderate to Severe Acne Scars


eMediNexus    24 February 2023

Managing acne scars is challenging, and therapies are divided into nonsurgical and surgical. Highly Purified Technology Polynucleotides (PN-HPT) is a compound that includes a mixture of DNA polymers of different lengths. Considerable studies have shown that PN-HPT also serves as an energy source, thus influencing cellular growth and cell vitality.


The present study assessed the improvement in dermal quality and acne scars after PN-HPT versus placebo according to Antera 3D and the patient responses to the patient satisfaction questionnaire after comparing pre-treatment and post-treatment photographs at 1 and 3 months.


It included women aged 30 to 50 years with grade 3 to 4 moderate to severe atrophic scars according to the Goodman classification, nonsmokers and without a history of any active acne during the past 5 years. It treated 10 patients (PN-HPT group) with 4.0 mL of PN-HPT and 10 patients (control) with 4.0 mL of normal saline. 


The study witnessed the inclusion of 20 women, and only patients in the PN-HPT group showed significant improvement at 1 and 3 months after treatment compared with baseline.


This study shows that PN-HPT in monotherapy is a safe and effective treatment for atrophic scar acne compared with a placebo. Further studies are necessary to investigate the clinical effectiveness in a larger cohort of patients and for a longer follow-up.


Source: Araco A, Araco F. Preliminary prospective and randomized study of highly purified polynucleotide vs. placebo in treatment of moderate to severe acne scars. Aesthet Surg J. 2021;41(7):NP866-NP874.  

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