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The relationship between lipoprotein(a) and diabetic kidney disease.

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eMediNexus    27 February 2023

The current knowledge about the role of lipid metabolism in diabetic kidney disease (DKD) is limited.

A recent study that investigated the correlation between lipid metabolism and renal function, as well as renal pathological grade/score in DKD patients, described-

Lp (a) levels correlated with serum creatinine, blood urea nitrogen, estimated glomerular filtration rate, 24-h proteinuria, urine microalbumin, urine albumin creatinine ratio, glomerular basement membrane thickness, and glomerular grade.

Wang A, Zhang S, Li Y, Zhu F, Xie B. Study on the relationship between lipoprotein (a) and diabetic kidney disease. Journal of Diabetes and its Complications. 2023;37(1). https://doi.org/10.1016/j.jdiacomp.2022.108378.

Good performance of Lp (a) is an indicator to assess CKD stage 4–5, 24h UPro > 3.5 g, and glomerular grade III-IV.

 
 

Hence the elevated levels of Lp (a), which are associated with decreased GFR, increased proteinuria, and renal pathological progression can be used to monitor changes in DKD patients.

 
 

REFERENCE-

Wang A, Zhang S, Li Y, Zhu F, Xie B. Study on the relationship between lipoprotein (a) and diabetic kidney disease. Journal of Diabetes and its Complications. 2023;37(1). https://doi.org/10.1016/j.jdiacomp.2022.108378.

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