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Alternative Topical Therapy for Zoophilic Dermatomycoses: Comparative Assessment of Luliconazole and Terbinafine 1% Cream

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Emedinexus    23 June 2023

Dermatomycoses of zoophilic origin, particularly those caused by Trichophyton mentagrophytes, often present significant therapeutic challenges. The emergence of terbinafine-resistant strains due to squalene epoxidase (SQLE) gene mutations has further complicated treatment options. Therefore, exploring alternative therapies to the commonly used terbinafine is warranted.

 

The present study assessed the in vivo effectiveness of topical therapy with luliconazole or terbinafine 1% cream. It evaluated the therapeutic efficacy using various methods, including direct examination in KOH with DMSO, qPCR analysis with pan-dermatophyte primers and culturing. Additionally, it conducted in vitro susceptibility tests to determine the antifungal activity of luliconazole and terbinafine.

 

The results revealed:

 

  • Significantly higher antifungal activity of luliconazole compared to terbinafine against dermatomycoses caused by T. mentagrophytes
  • The geometric mean of the minimum inhibitory concentration (MIC) value for luliconazole against all strains of T. mentagrophytes was 0.002 μg/mL, whereas, for terbinafine, it was 0.004 μg/mL. 
  • In all cases studied, 28-day local therapy with luliconazole completely eradicated the causative agent of infection.

Considering the increasing reports of challenging-to-treat dermatophytoses caused by zoophilic terbinafine-resistant strains, using 1% luliconazole cream can be considered an alternative solution for topical therapy.

 

Source: Mycoses. 2021;64(8):967-75. 

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