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Emedinexus 23 June 2023
Dermatomycoses of zoophilic origin, particularly those caused by Trichophyton mentagrophytes, often present significant therapeutic challenges. The emergence of terbinafine-resistant strains due to squalene epoxidase (SQLE) gene mutations has further complicated treatment options. Therefore, exploring alternative therapies to the commonly used terbinafine is warranted.
The present study assessed the in vivo effectiveness of topical therapy with luliconazole or terbinafine 1% cream. It evaluated the therapeutic efficacy using various methods, including direct examination in KOH with DMSO, qPCR analysis with pan-dermatophyte primers and culturing. Additionally, it conducted in vitro susceptibility tests to determine the antifungal activity of luliconazole and terbinafine.
The results revealed:
Considering the increasing reports of challenging-to-treat dermatophytoses caused by zoophilic terbinafine-resistant strains, using 1% luliconazole cream can be considered an alternative solution for topical therapy.
Source: Mycoses. 2021;64(8):967-75.
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