The clinical benefits of licorice (Glycyrrhiza spp.) have been a subject of investigation for numerous years. It has a historical application in treating various ailments. Diverse constituents exhibiting distinct characteristics have been isolated from Glycyrrhiza spp. extracts.

The objective of a review was to provide a comprehensive summary of the present understanding regarding the pharmacological effectiveness and safety of licorice extract components in addressing the underlying causes of acne vulgaris (AV) and the associated post-inflammatory hyperpigmentation (PIH). Licorice extract has been found to possess anti-androgenic, antimicrobial, anti-inflammatory, antioxidant, depigmenting, and skin-regenerating properties. These attributes suggest that licorice extract may combat AV and PIH through various pharmacological mechanisms.

Licorice extract displays a wide-ranging spectrum of activity and holds potential as an effective and secure option for addressing AV and its related PIH. However, substantiated by evidence-based clinical trials, the efficacy and safety of licorice extract require validation. This review offers fresh insights that could guide further exploration in the context of extensive controlled clinical trials.

Source:Raoufinejad K, Rajabi M, Sarafian G. Journal of Pharmaceutical Care. 2020 Dec 28:186-95.