In a recent study published in the Journal of Prosthodontics, researchers suggested that the application of MI Paste, a dental therapeutic containing casein-phosphopeptide-amorphous-calcium-phosphate (CPP-ACP) on the fitting surface of complete dentures may help mitigate the risk of dental caries among older adults with removable dentures. 

Older adults with removable dentures often experience elevated caries and salivary gland dysfunction rates. The study investigated the impact of MI Paste on salivary conditions when applied to the fitting surface of complete dentures.

The research recorded salivary flow rate and pH at baseline and 15 minutes after applying 1 mL of CPP-ACP paste to the fitting surface of each participants denture. Statistical analyses were conducted to compare salivary parameters between baseline and post-CPP-ACP paste application and between participants with and without self-reported xerostomia.

The findings showed that of the 28 participants, 11 reported xerostomia. It was observed that CPP-ACP-paste application was associated with decreased pH reduction during acid challenge compared to baseline (0.95 ± 0.24 vs. 1.54 ± 0.53) and a higher final pH following acid challenge (5.93 ± 0.34 vs. 5.40 ± 0.66). Although flow rates observed post-CPP-ACP paste application were more significant than those at baseline, the difference was not statistically significant (0.67 ± 0.44 mL/min vs. 0.55 ± 0.34 mL/min). Also, no significant differences were found in any salivary parameters between participants with or without self-reports of xerostomia.

(Source:https://medicaldialogues.in/dentistry/news/mi-paste-reduces-risk-of-dental-caries-in-patients-with-removable-dentures-121648 )