The purpose of a study published in The Journal of Pediatrics was to compare the effectiveness of a mixture of acacia fiber, psyllium fiber, and fructose (AFPFF) with polyethylene glycol 3350 combined with electrolytes (PEG+E) in treating children with chronic functional constipation (CFC); and to evaluate the safety and effectiveness of these therapies in the treatment of children with CFC. In this randomized, open label, prospective, controlled, parallel-group study, 100 children diagnosed with CFC according to the Rome III Criteria were enrolled. These children were randomly divided into two groups; vis, 50 children received AFPFF 16.8 g daily, and 50 children were given PEG+E 0.5 g/kg daily, for 8 weeks. The results displayed a compliance rate of 96% for PEG+E, which was higher than that for AFPFF. While a marked improvement of constipation was seen in both the groups. Moreover, after 8 weeks of treatment, 83% of the children in PEG+E group showed improvements in symptoms. Additionally, neither of these therapies resulted in any clinically significant side effects during the study period. From the results, it was concluded that PEG+E is safe for use in CFC treatment and is better tolerated in children.