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Higher Thiazide Doses Linked to Reduced Kidney Stone Events

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Emedinexus    04 September 2024

A study found that higher doses of thiazide diuretics lead to more significant reductions in urine calcium levels and fewer symptomatic kidney stone events. Adjusting thiazide dosage could be crucial for effective kidney stone prevention.

 

A recent study published in JAMA Network Open found that higher doses of thiazide diuretics are associated with more significant reductions in urine calcium levels, correlating with fewer symptomatic kidney stone events.

 

 Researchers used the Medicare-Litholink Database to analyze 634 adults with kidney stones, aged 67.6 years on average, who were prescribed thiazides (hydrochlorothiazide, chlorthalidone, or indapamide). Participants underwent follow-up urine collections after filling their prescriptions. Thiazide dosages were categorized as low, medium, or high, and their effects on urine calcium levels were assessed. 

 

Results showed that low doses reduced calcium levels by 18.9%, medium doses by 25.5%, and high doses by 28.4%. This reduction in calcium levels was linked to a lower incidence of symptomatic kidney stone events over four years. The cumulative incidence of stone events was 28.8% for those with low calcium reductions, compared to 19.5% and 18.0% for medium and high reductions, respectively.

 

(Source:https://www.medscape.com/viewarticle/boosting-thiazide-dosage-can-reduce-kidney-stone-risk-2024a1000fx9 )

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