CT-ADP Point-of-Care Assay Predicts Paravalvular Aortic Regurgitation following Transcatheter Aortic Valve Replacement.


eMediNexus    02 April 2018

The purpose of a new study published in Thrombosis and Haemostasis was to examine whether closure time (CT) adenosine diphosphate (ADP) could detect paravalvular aortic regurgitation (PVAR) at 30 days, and bleeding complications following transcatheter aortic valve replacement (TAVR). In this study, significant PVAR was diagnosed in 44 out of 219 patients. The findings showed important reduction of CT-ADP in patients without PVAR, whereas CT-ADP improvement was absent in significant PVAR patients. On the other hand, CT-ADP > 180 seconds and a self-expandable valve were the sole independent predictors of 30-day PVAR. At follow-up, post-procedural CT-ADP >180 seconds was identified as an independent predictor of major/life-threatening bleeding. Meanwhile, major or life-threatening bleedings were at their highest levels in patients with post-procedural CT-ADP > 180 seconds. From the results, it was inferred that post-procedural CT-ADP > 180 seconds is an independent predictor of significant PVAR 30 days after TAVR and may independently contribute to major/life-threatening bleedings.

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