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Optimal Timing for Intravenous Paracetamol Administration to Reduce Postoperative Shivering

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Emedinexus    18 November 2024

A recently published study delved into the timing of intravenous paracetamol (PCM) administration and its impact on postoperative shivering. Postoperative shivering, often stemming from an elevated core body temperature set point, was the focal point of the investigation. Intravenous paracetamol, known to inhibit prostaglandins and reduce the hypothalamic temperature set point, was administered at different intervals to discern its efficacy in mitigating postoperative shivering.


The trial encompassed 225 ASA I/II adult patients undergoing elective surgeries under general anesthesia (GA). The patients were strategically grouped to receive PCM immediately after anesthesia induction, 30 minutes before completion of surgery, or no PCM at all. The study's findings revealed that administering PCM 30 minutes before the conclusion of surgery emerged as the most effective approach, resulting in the lowest incidence of postoperative shivering and hypothermia.


Additionally, this timing correlated with a prolonged time to analgesic requirement compared to PCM administration after anesthesia induction or no PCM. Notably, the researchers highlighted that the peak hypothermic action of PCM occurs approximately 120 minutes after administration. In conclusion, the study advocates for the strategic administration of PCM close to the end of surgery as it maximizes its benefits in preventing shivering and providing adequate postoperative analgesia.


(Source:https://medicaldialogues.in/anesthesia/news/how-postoperative-shivering-is-affected-by-time-of-paracetamol-administration-during-surgery-122555 )

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