A study published online in the Journal of Clinical Endocrinology and Metabolism has suggested that children born of mothers with polycystic ovarian syndrome who took metformin during pregnancy were more likely to have weight issues as toddlers. Women randomized to metformin for gestational diabetes delivered children who weighed more and had higher BMI at age 4 years. Additionally, more 4-year-olds were considered overweight or obese among those exposed to metformin in utero (32% versus 18% for placebo). Researchers followed 182 children born to mothers who were given daily metformin or placebo during pregnancy in the PregMet (Metformin in Pregnant PCOS Women) trial or its pilot study. Metformin did not appear to have any impact on birth weight; however, the difference in both weight and BMI was noted in offspring as early as 6 months after delivery.