The aim of a new study published in the World Journal of Pediatrics was to evaluate leukocytes, C-reactive protein, pro-inflammatory and anti-inflammatory cytokines, and neopterin levels in children with functional constipation. This study enrolled 76 children with constipation and 71 healthy controls with a mean age of 7.12 ± 3.46 years and 7.32 ± 4.33 years, respectively. In these individuals, leukocytes, C-reactive protein, interleukin (IL)-1β, IL-6, IL-10, IL-12, tumor necrosis factor-alpha (TNF-α) and neopterin levels were assessed. The results revealed that the mean IL-6, IL-12 and neopterin levels were significantly higher in constipated children than in healthy controls. On the contrary, leukocyte and thrombocyte counts, C-reactive protein, and IL-1β, IL-10 and TNF-α levels did not show any difference between the two groups. Hence, it was found that IL-6, IL-12 and neopterin levels of constipated patients were higher than those of controls, which hinted at the presence of subclinical inflammation in children with functional constipation.