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Very-Low-Calorie Ketogenic Diet Shifts Monocyte Distribution, may Help Combat Obesity-Related Inflammation

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Emedinexus    01 June 2025

A study shows that very low-calorie ketogenic diets (VLCKDs) can shift monocyte distribution in obese individuals, potentially reducing inflammation. This modulation of immune function suggests VLCKDs as a promising strategy for improving obesity-related inflammation.

 

A study published in Nutrients investigated the impact of very low-calorie ketogenic diets (VLCKDs) on monocyte subset distribution in obese individuals. Obesity is closely linked to chronic low-grade inflammation, which contributes to cardio-metabolic comorbidities, and altered monocyte subsets have been associated with increased inflammation. 


The study involved 36 participants divided into four groups: healthy controls, individuals with obesity who received no dietary intervention, and individuals with obesity on either a low-calorie diet (LCD) or VLCKD for 28 days. Blood samples were analyzed using flow cytometry to assess the distribution of classical monocytes (CMs), intermediate monocytes (IMs), and non-classical monocytes (NCMs). 


The results showed that obesity led to increased IMs and NCMs, with a decrease in CMs compared to healthy controls. The VLCKD caused a shift towards increased CMs and reduced IMs and NCMs, bringing monocyte distribution closer to that of healthy individuals. No significant changes were observed in the LCD group. 


(Source:https://www.mdpi.com/2072-6643/17/2/312 )

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