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The Hindu Bureau 04 June 2025
IISc scientists have developed a nanozyme that controls harmful blood clots by reducing oxidative stress. Early tests show promise in preventing thrombosis with plans for further clinical studies.
Scientists at the Indian Institute of Science (IISc) have developed an artificial metal-based nanozyme that could help prevent abnormal blood clotting associated with conditions such as pulmonary thromboembolism (PTE). Normally, platelets form clots to protect injured blood vessels. However, in diseases such as PTE or COVID-19, excess reactive oxygen species (ROS) cause the over-activation of platelets, leading to the formation of harmful clots.
Led by Prof. G. Mugesh, the team developed vanadium pentoxide (V2O5) nanozymes that mimic natural antioxidant enzymes to control ROS levels and reduce clot formation. Tests on human platelets showed spherical nanozymes effectively prevented excess aggregation. In mouse models of PTE, the nanozyme lowered thrombosis and improved survival without toxicity.
The researchers aim to study its potential against ischemic stroke next and are optimistic about future clinical trials, given the promising results with human platelets.
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