A study published in the journal of OncoTargets and Therapy revealed that increased hematopoietic pre B cell leukemia transcription factor interacting protein HPIP expression may contribute to the progression and metastasis of cervical cancer CC . In addition it may also be considered a novel biomarker for predicting the prognosis of CC. The study was performed with an aim of exploring the association of HPIP expression status with the clinicopathological variables and survival outcomes of patients with CC. The researchers compared the HPIP expression of 119 samples from CC tissues 20 from cervical intraepithelial tissues and 20 from normal cervical tissues by using immunohistochemical staining. The results showed that the ratio of elevated HPIP expression was higher in CC tissues in comparison to cervical intraepithelial neoplasia and normal cervical tissues. Moreover a link was found between HPIP and clinicopathological factors such as histological grade stromal infiltration lymph node metastasis lymphovascular space invasion LVSI and recurrence. Multivariate Cox regression analysis reported that high HPIP expression and the International Federation of Gynecology and Obstetrics stage lymph node metastasis and LVSI were independent prognostic factors. An independent association of HPIP expression and LVSI with lymph node metastasis was also documented.