A new study published in the Zhongua Yu Fang Yi Xue Za Zhi investigated the effect of pre-pregnancy weight and the increase in gestational weight on fetal growth restriction. This cohort study recruited 3,212 maternal-singleton pairs who received their first antenatal care and were willing to undergo their prenatal care and delivery in Ma anshan Maternity and Child Care Centers. The findings revealed that the incidence of fetal growth restriction in this cohort was 9.7%. The incidence of fetal growth restriction in pre-pregnancy underweight group was 14.9% higher than that in normal pre-pregnancy weight group. While the incidence of fetal growth restriction in inadequate increase of gestational weight group was 17.9% higher than the appropriate increase of weight group. In addition, in comparison with normal pre-pregnancy weight group, pre-pregnancy underweight was a risk factor for fetal growth restriction. Furthermore, when compared to the appropriate increase of gestational weight group, inadequate weight increase during pregnancy was a risk factor for fetal growth restriction. Hence, it was inferred that pre-pregnancy underweight and inadequate increase of gestational weight would increase the risk of fetal growth restriction without interaction.