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Diabetes and CKD in the United States Population, 2009-2014.

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eMediNexus    24 October 2017

A new study published in Clinical Journal of the American Society examined associations of diabetes with clinical manifestations of chronic kidney disease (CKD), independent of age and blood pressure (BP), and the extent to which diabetes contributes to the overall prevalence of CKD in the United States. This cross-sectional study included 15,675 participants from the National Health and Nutrition Examination Surveys, between 2009 and 2014. The results revealed that for 2279 participants with diabetes and in 13,396 without diabetes, the estimated prevalence of any CKD was 25% and 5.3%, respectively; albumin-to-creatinine ratio ≥30 mg/g was 16% and 3.0%, respectively; albumin-to-creatinine ratio ≥300 mg/g was 4.6% and 0.3%, respectively; estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m2 was 12% and 2.5%, respectively; and eGFR <30 ml/min per 1.73 m2 was 2.4% and 0.4%, respectively. Furthermore, adjusting for demographics and several aspects of BP, prevalence differences were 14.6%, 10.8%, 4.5%, 6.5%, and 1.8%, respectively. Moreover, approximately 24% of CKD among all United States adults was attributable to diabetes, after adjusting for demographics. Thus, it was inferred that diabetes is strongly associated with both albuminuria and reduced GFR independent of demographics and hypertension, contributing substantially to the burden of CKD in the United States.

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