The objective of a new study published in the Indian Journal of Gastroenterology was to identify demography, symptom, and colonoscopic parameters that can predict dyssynergic defecation (DD) among patients with chronic constipation (CC) and to compare the profile among male and female patients with DD. The study involved data collection from three centers between June 2014 and May 2017, which included the age, gender, symptom duration, form and consistency of stools, digital examination findings, and colonoscopy and anorectal manometry (ARM) reports. Patients were categorized based on the findings – group I (normal results) and group II (DD). Further, a gender-wise subset analysis was undertaken for those with the normal and abnormal ARMs. The results showed normal ARMs for 55% of the patients evaluated for CC, while 45% of these patients were detected with DD. Male sex, straining during defecation, bleeding per rectum, and abnormal colonoscopic diagnosis were significantly higher in group II. Meanwhile, bleeding per rectum and absence of urge to defecate were more common in males. Whereas, straining, digital evacuation, and hard stools were prevalent in females with DD. Hence, it was concluded that straining during defecation, bleeding per rectum, and abnormal colonoscopy findings are more common in patients with DD. Symptoms of bleeding per rectum and absence of urge to defecate in men and straining during defecation in female patients are significantly associated with DD. Besides, symptoms differ in males and females with DD.