The purpose of a new study published in the Iranian Journal of Medical Sciences was to translate and culturally adapt the Patient Assessment of Constipation Quality of Life (PAC-QOL) questionnaire and to assess its reliability and validity among Persian patients with chronic constipation. Here, 100 patients, with a mean age of 40.51±13.67 having constipation, were recruited for validity measurement and 20 patients were re-examined for reliability. The results confirmed the content validity of the PAC-QOL questionnaire and there was no floor/ceiling effect. Construct validity also was confirmed based on the hypothesis test. The overall Cronbachs alpha of the PAC-QOL questionnaire was 0.92 and the overall intra-class correlation coefficient of the questionnaire was 0.88. Hence, it was inferred that the Persian version of the PAC-QOL questionnaire has good validity and reliability in evaluating chronic constipation. Hence, it was stated that Persian researchers and clinicians can benefit from this questionnaire in further research and assessment of treatment outcomes.