A new study published by Nutrients aimed to evaluate changes in intestinal transit time and gastrointestinal (GI) symptoms in chronic constipation (CC) patients who consumed polydextrose. This was a randomized, double-blind, placebo-controlled trial, wherein 128 adults with CC received 8 g or 12 g polydextrose or placebo, daily for 4 weeks. Transit time was assessed by radiopaque marker distribution after 2-weeks intervention. Bowel habits, GI symptoms and quality of life (QOL) were assessed by questionnaire, including the Patient-Assessment of Constipation (PAC) Symptoms (SYM), and PAC-QOL. It was observed that after 2-weeks of intervention, there was no reduction in the transit time in any group and post 2- or 4-weeks of intervention, no improvements were noted in stool frequency or consistency in either of the groups. After 2-weeks of intervention with 8 g/day polydextrose an improvement was observed in the PAC-SYM rectal score. Additionally, after 4-weeks of intervention both rectal and stool scores improved; however the improvement in the QOL satisfaction score was not significant. Hence, it was concluded that 2-weeks consumption of 8 or 12 g/day polydextrose does not significantly improve physiological measures of gut function in CC adults. The findings suggested that longer term consumption may improve clinical measures.