A recent article published in the Journal of Pediatric Gastroenterology and Nutrition reported that according to international guidelines, polyethylene glycol (PEG) is the laxative of first choice in the treatment of functional constipation in children, both for disimpaction and for maintenance treatment. It was discussed that PEG acts as an osmotic laxative and its efficacy is dose dependent. PEG is highly effective, has a good safety profile, and is well tolerated by children. Meanwhile, only minor adverse events have been reported with its use. Hence, it was stated that the use of PEG in children is safe. In patients predisposed to water and electrolyte imbalances monitoring of serum electrolytes should be considered.