A new study published in the Journal of Obstetrics and Gynecology of India compared the incidence of infection in patients of episiotomy, with or without the use of prophylactic antibiotics, and other morbidities associated with episiotomy and the role of antibiotics in their prevention and treatment. This was an open-labelled, randomized, interventional trial conducted in the Department of Obstetrics and Gynecology at BYL Nair Charitable Hospital, Mumbai, from October 2014 to October 2015, wherein 300 women subjected to episiotomy during normal vaginal delivery in the labor ward were enrolled. These women were randomly divided into two study groups. In group A, a 5-day course of prophylactic antibiotics including cefixime 200 mg BD and metronidazole 400 mg TDS was given, while group B did not receive prophylactic antibiotics. The two groups were followed up for 5-days postpartum and observed for signs and symptoms of infection. The results showed that the presence of infection - any positive finding including redness, pain, swelling, wound discharge or wound gape - was 0.7% in group A and was 2% in group B. There was no increased incidence of infection in either group, whether antibiotics were given or not. In summary, it was stated that prophylactic antibiotics did not decrease the incidence of infection in episiotomy following normal vaginal delivery in uncomplicated cases. Yet, further studies are required for a more definitive conclusion.